Biotrexate 500mg Injection

METHOTREXATE
₹429.40 ₹1,131.00 (You Save ₹702)

1 Vial(s)

Sourced from: ZYDUS CADILA
62% OFF
★★★★★ 4.8 On Google
₹429.40 MRP: ₹1,131.00 62% OFF

Inclusive of all taxes

1 Vial(s)
₹429.40/Unit
Rx Prescription Required
Salt Composition
METHOTREXATE
Marketer
ZYDUS CADILA
🚚
Dispatch: Tomorrow
if Order in: --h --m --s

Quick overview

Biotrexate 500mg Injection contains METHOTREXATE and is marketed by ZYDUS CADILA. Country of origin: India. This pack is 1 Vial(s), priced at ₹429.40 inclusive of all taxes (about 62% off MRP). A valid prescription is required to order this medicine. On MedsRight, Biotrexate 500mg Injection is organised under the Rheumatology speciality and the Arthritis condition category.

Know about Biotrexate 500mg Injection in 30 seconds

From salt and price to delivery — the essentials in one short read, in about 30 seconds time.

  • Salt composition: METHOTREXATE — that is what goes into Biotrexate 500mg Injection as the active part of the medicine. more options with same salt

  • Pack & price: You pay ₹429.40 for 1 Vial(s), including all taxes. The MRP printed on the pack is ₹1,131.00 — you save roughly 62% versus that.

  • Per-unit value: Roughly ₹429.40 per unit — handy when you want to compare this pack with a bigger or smaller one.

  • Medical speciality: MedsRight files Biotrexate 500mg Injection under “Rheumatology” — the same kind of department-wise grouping you see in clinics and hospitals. Explore this speciality

  • Condition category: We link it to “Arthritis” so you can find it when you shop by health topic, not only by salt or brand. Browse this condition

  • Marketer: ZYDUS CADILA is the company behind this brand pack — the name you will usually see on invoices and packaging.

  • Country of origin: Country of origin for this pack is India.

  • Prescription: You will need a valid prescription to buy Biotrexate 500mg Injection. Take it only the way your doctor told you.

  • Storage & handling: Keep it like any everyday medicine at room temperature, unless the pack asks for something special (fridge, away from light, etc.).

  • Dispatch: We use Indian Standard Time. Order before 3:00 PM and your parcel is usually lined up to leave the warehouse the next working day (“Tomorrow”). After 3:00 PM, it slips to the following slot (“Day after”).

  • Doorstep delivery: After it leaves the warehouse, most addresses get it in about 3–4 days, depending on pincode and courier. Rural or remote areas can take a bit longer.

  • Availability: It should be possible to add Biotrexate 500mg Injection to your cart right now. Stock can run out if many people order at once, so finish checkout if you need it soon.

Detailed Information

Introduction

Biotrexate 500mg Injection contains methotrexate, a powerful anti-metabolite and immunosuppressant medication used to treat serious conditions including certain cancers, severe psoriasis, and rheumatoid arthritis in adults. This injectable medicine works by slowing the growth and spread of cancer cells and suppressing an overactive immune system in autoimmune diseases. Biotrexate 500mg Injection must only be used under strict medical supervision as it requires regular monitoring through blood tests and clinical follow-ups. This medicine is administered by a healthcare professional either into a vein (intravenously) or into muscle tissue (intramuscularly), and should never be self-administered.

Key points

  • Used to treat acute lymphocytic leukemia (ALL), meningeal leukemia, non-Hodgkin's lymphoma, osteosarcoma, cutaneous T-cell lymphoma, breast cancer, and head and neck cancer
  • Effective for severe psoriasis and rheumatoid arthritis in adults
  • Requires regular doctor visits and laboratory tests to monitor safety
  • Not suitable for patients with kidney or liver problems, blood disorders, or weakened immune systems

Therapeutic Uses

  • Treatment of specific cancers including acute lymphocytic leukemia, meningeal leukemia, non-Hodgkin's lymphoma, osteosarcoma, cutaneous T-cell lymphoma, breast cancer, and head and neck cancer
  • Management of severe psoriasis in adults
  • Treatment of rheumatoid arthritis in adults

How it Works

Biotrexate 500mg Injection works by blocking an enzyme called dihydrofolic acid reductase, which interferes with DNA synthesis, repair, and cell division. This action is particularly effective against rapidly dividing cells such as cancer cells, bone marrow cells, and certain skin and intestinal cells. In cancer treatment, slowing cell division prevents tumors from growing and spreading. In autoimmune diseases like rheumatoid arthritis and psoriasis, this immunosuppressant effect helps reduce the body's abnormal immune response, providing relief from symptoms.

How to Take

Biotrexate 500mg Injection is administered only by a healthcare professional in a clinical setting. Your doctor will determine the appropriate dose, frequency, and duration based on your specific condition, body weight, and overall health status. This medicine is given either as an intravenous (IV) injection into a vein or as an intramuscular (IM) injection into muscle tissue. Always follow your doctor's instructions exactly and do not attempt to administer this injection yourself.

Instructions

  • Receive the injection from a qualified healthcare professional only
  • Attend all scheduled appointments as prescribed by your doctor
  • Inform your healthcare provider of any symptoms or side effects before the next dose
  • Do not skip doses without consulting your doctor

Timing

As determined by your doctor based on your treatment plan

Missed dose

If you miss a scheduled injection appointment, contact your healthcare provider immediately to reschedule your appointment as soon as possible.

Overdose

Overdose with Biotrexate 500mg Injection can be serious. If you suspect an overdose or accidental administration of too much medication, seek emergency medical help immediately or contact your nearest poison control center.

Side Effects

  • Hair loss, rash, photosensitivity (increased sun sensitivity), diarrhea, nausea, and vomiting
  • Decreased white blood cell and platelet counts, increasing infection and bleeding risk
  • Dizziness, drowsiness, tiredness, fever, shivering, blurred vision, and general weakness
  • Serious allergic reactions, coughing or spitting up blood, chest pain, muscle weakness, and one-sided body weakness

Safety Advice

Pregnancy

Unsafe

Biotrexate 500mg Injection can cause serious birth defects and harm to the developing fetus. This medication is absolutely contraindicated during pregnancy at any stage.

Tip: Do not use this medicine if you are pregnant or suspect you may be pregnant. Use effective contraception during treatment and for 6 months after your last dose. Inform your doctor immediately if you become pregnant during treatment.

Breastfeeding

Unsafe

Biotrexate 500mg Injection passes into breast milk in small amounts and may harm your nursing baby.

Tip: Do not breastfeed while receiving this medication. Discuss feeding options with your doctor before starting treatment.

Liver Function

Consult Doctor

Biotrexate 500mg Injection can cause liver damage. It is contraindicated in patients with acute liver failure and requires careful monitoring in those with existing liver disease.

Tip: Inform your doctor if you have any liver disease or liver problems. Dose adjustments may be necessary based on your liver function test results.

Kidney Function

Consult Doctor

Patients with kidney problems may require dose adjustments as the kidneys help eliminate this medicine from the body.

Tip: Tell your doctor if you have kidney disease or mild kidney problems before starting treatment.

Lung Function

Consult Doctor

Biotrexate 500mg Injection should be used cautiously in patients with existing lung diseases due to potential respiratory complications.

Tip: Inform your doctor if you have any lung disorders or respiratory conditions before initiating therapy.

Alcohol Use

Unsafe

Consuming alcohol while taking Biotrexate 500mg Injection significantly increases the risk of liver damage.

Tip: Avoid all alcoholic beverages during your entire treatment course.

Driving and Operating Machinery

Unsafe

This medication may cause side effects such as dizziness, drowsiness, blurred vision, and confusion that impair your ability to drive safely.

Tip: Do not drive, operate heavy machinery, or perform tasks requiring alertness if you experience any of these side effects.

Blood Disorders

Unsafe

Biotrexate 500mg Injection is contraindicated in patients with existing blood disorders as it can further suppress blood cell production.

Tip: Do not use this medicine if you have blood disorders. Inform your doctor of any history of anemia, low white blood cell count, or low platelet count.

Immune System

Unsafe

Patients with weakened or compromised immune systems should not use this medication as it further suppresses immune function.

Tip: Inform your doctor if you have a weakened immune system, HIV/AIDS, or are taking immunosuppressive medications.

Fertility

Consult Doctor

Biotrexate 500mg Injection can affect fertility in both men and women and may cause birth defects if conception occurs during or shortly after treatment.

Tip: Discuss fertility concerns with your doctor before starting treatment. Both male and female patients should use effective contraception during treatment and for 6 months after the last dose. Male patients whose partners have reproductive potential should use effective birth control for 3 months after treatment.

FAQs

What are the most common side effects of Biotrexate 500mg Injection?
The most frequently reported side effects of Biotrexate 500mg Injection include hair loss, skin rashes, increased sun sensitivity requiring sunscreen protection, diarrhea, nausea, vomiting, dizziness, tiredness, fever, and blurred vision. Additionally, this medication commonly reduces white blood cell and platelet counts, which may increase your susceptibility to infections and bleeding. While many of these side effects are manageable and may decrease over time, you should report any persistent or bothersome symptoms to your healthcare provider.
What to expect after taking Biotrexate 500mg Injection for ectopic pregnancy?
Biotrexate 500mg Injection is sometimes used as a medical treatment for ectopic pregnancy to stop the growth of pregnancy tissue. Following treatment, you may experience cramping, vaginal bleeding, and general abdominal discomfort as the pregnancy tissue is absorbed by your body. This process typically takes several weeks. Your doctor will monitor your hormone levels through blood tests to confirm successful treatment. Attend all follow-up appointments and contact your doctor immediately if you experience severe abdominal pain, heavy vaginal bleeding, dizziness, or signs of infection.
How to boost the immune system while taking Biotrexate 500mg Injection?
While taking Biotrexate 500mg Injection, your immune system is intentionally suppressed as part of your treatment. Rather than 'boosting' immunity, focus on protecting yourself from infections by washing your hands frequently, avoiding crowds and people who are sick, and maintaining good hygiene practices. Avoid live vaccines during treatment. Eat a balanced, nutritious diet rich in vitamins and minerals, get adequate rest, manage stress, and stay hydrated. Ask your doctor about appropriate supplements, as some may interact with your medication. Your doctor may recommend folic acid supplementation at specific times to help manage side effects. Never take supplements or make dietary changes without consulting your healthcare provider first.
Can I stop taking Biotrexate 500mg Injection?
You should never stop taking Biotrexate 500mg Injection without explicit permission from your doctor, as abruptly discontinuing treatment can be dangerous and reduce the effectiveness of your therapy. Stopping medication prematurely may allow your cancer to progress, cause your rheumatoid arthritis or psoriasis symptoms to return, or lead to serious complications. If you are experiencing intolerable side effects or have concerns about your treatment, discuss these with your doctor immediately. Your healthcare provider may adjust your dose, change your treatment schedule, or recommend alternative medications rather than stopping therapy entirely. Always follow your doctor's guidance regarding when and how to discontinue this medication.
How long can you take Biotrexate 500mg Injection?
The duration of Biotrexate 500mg Injection treatment varies significantly depending on your specific condition, how well you respond to the medication, and your overall health status. Cancer patients may require treatment for several months to years, while patients with rheumatoid arthritis or psoriasis may take this medication long-term for disease management. Your doctor will determine the appropriate treatment length based on regular monitoring, blood tests, and assessment of your condition's response to therapy. Some patients may take this medication indefinitely to maintain disease control, while others may eventually discontinue it once remission is achieved. Never decide on your own how long to continue treatment; always follow your doctor's recommendations and attend regular check-ups to assess whether continued treatment is necessary.
How do I know if Biotrexate 500mg Injection is working?
Your doctor will monitor whether Biotrexate 500mg Injection is working through multiple methods including regular blood tests, imaging studies, physical examinations, and assessment of your symptoms. For cancer treatment, imaging scans and tumor markers help measure how well the cancer is responding. For rheumatoid arthritis, your doctor will evaluate joint swelling, pain reduction, and improved mobility. For psoriasis, visible improvement in skin lesions indicates treatment effectiveness. You may notice gradual symptom improvement over weeks to months of treatment. Keep all scheduled appointments and laboratory tests, as these are essential for determining treatment effectiveness. Communicate openly with your doctor about any changes in your symptoms—improvement or worsening—to help guide your ongoing care and any necessary treatment adjustments.

Drug Interactions

Biotrexate 500mg Injection can interact with many other medications, reducing its effectiveness or increasing the risk of serious side effects. It is essential to inform your doctor about all medicines you are taking, including prescription drugs, over-the-counter medications, vitamins, nutritional supplements, and herbal products before starting treatment.

Major interactions

  • NSAIDs and other anti-inflammatory medications
  • Certain antibiotics
  • Blood thinners and anticoagulants
  • Folic acid supplements (timing must be coordinated with doctor)
  • Other cancer medications and immunosuppressants

Precautions

  • Avoid alcohol consumption, as it increases liver damage risk
  • Do not receive live vaccines while taking this medicine
  • Inform your doctor about recent vaccinations before starting treatment
  • Use effective contraception during treatment and for 6 months after the last dose
  • Report stomach ulcers or active infections to your doctor immediately

Important

Always provide your healthcare provider with a complete list of all medications and supplements. Some drug interactions can be serious and require dose adjustments or alternative treatments.

Storage Details

🌡 Store below 25°C (77°F)

Keep in a cool, dry place protected from light and moisture

  • Do not freeze the injection
  • Protect from direct light and excessive moisture
  • Keep out of reach of children and pets
  • Store in original packaging when possible

Fact Box

Active Ingredient
Methotrexate 500mg
Drug Class
Anti-metabolite and Immunosuppressant
Therapeutic Use
Cancer, severe psoriasis, rheumatoid arthritis
Prescription Required
Yes

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Quality Guaranteed

Guaranteed Temperature-Controlled Handling and Shipping — We maintain strict cold chain compliance for temperature-sensitive medicines from storage to delivery.

1

Carefully Packed

Every order is carefully packaged to maintain the required temperature for cold chain medicines and vaccines.

2

Verified Storage

Our pharmaceutical storage facilities are closely monitored and verified to ensure proper temperature conditions.

3

Insulated Shipping

We use insulated containers and temperature monitors for safe transport of temperature-sensitive medicines.

Rx Prescription Required

This medicine requires a valid prescription from a registered medical practitioner (doctor). As per Indian regulations, prescription-only medicines cannot be sold without a valid Rx.

You will need to upload your prescription during checkout. We accept clear images or PDF of your doctor's prescription.

Consult your doctor before taking any medicine. Never self-medicate with prescription drugs.

Medical Disclaimer

MedsRight is committed to providing consumers with reliable, accurate, and expert-validated healthcare information. All content published on this website is intended solely for general informational and educational purposes. It should not be considered a substitute for professional medical advice, diagnosis, or treatment.

We strongly encourage you to consult a qualified doctor or healthcare professional for guidance regarding any medical condition, symptoms, or medications. Never ignore or postpone seeking professional medical advice because of information you have read on MedsRight.

Our goal is to empower patients with trustworthy information while fully respecting and preserving the integrity of the doctor–patient relationship.

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