Topgraf 0.1% Ointment 10gm

TACROLIMUS
₹391.40 ₹456.94 (You Save ₹66)

1 Tube(s) Of 10gm

Sourced from: GLAXO SMITHKLINE PHARMACEUTICALS LTD
14% OFF
★★★★★ 4.8 On Google
₹391.40 MRP: ₹456.94 14% OFF

Inclusive of all taxes

1 Tube(s) Of 10gm
₹391.40/Unit
Rx Prescription Required
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Dispatch: Tomorrow
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Quick overview

Topgraf 0.1% Ointment 10gm contains TACROLIMUS and is marketed by GLAXO SMITHKLINE PHARMACEUTICALS LTD. Country of origin: India. This pack is 1 Tube(s) Of 10gm, priced at ₹391.40 inclusive of all taxes (about 14% off MRP). A valid prescription is required to order this medicine. On MedsRight, Topgraf 0.1% Ointment 10gm is organised under the Infectious Disease speciality and the Transplant condition category.

Know about Topgraf 0.1% Ointment 10gm in 30 seconds

From salt and price to delivery — the essentials in one short read, in about 30 seconds time.

  • Salt composition: TACROLIMUS — that is what goes into Topgraf 0.1% Ointment 10gm as the active part of the medicine. more options with same salt

  • Pack & price: You pay ₹391.40 for 1 Tube(s) Of 10gm, including all taxes. The MRP printed on the pack is ₹456.94 — you save roughly 14% versus that.

  • Per-unit value: Roughly ₹391.40 per unit — handy when you want to compare this pack with a bigger or smaller one.

  • Medical speciality: MedsRight files Topgraf 0.1% Ointment 10gm under “Infectious Disease” — the same kind of department-wise grouping you see in clinics and hospitals. Explore this speciality

  • Condition category: We link it to “Transplant” so you can find it when you shop by health topic, not only by salt or brand. Browse this condition

  • Marketer: GLAXO SMITHKLINE PHARMACEUTICALS LTD is the company behind this brand pack — the name you will usually see on invoices and packaging.

  • Country of origin: Country of origin for this pack is India.

  • Prescription: You will need a valid prescription to buy Topgraf 0.1% Ointment 10gm. Take it only the way your doctor told you.

  • Storage & handling: Keep it like any everyday medicine at room temperature, unless the pack asks for something special (fridge, away from light, etc.).

  • Dispatch: We use Indian Standard Time. Order before 3:00 PM and your parcel is usually lined up to leave the warehouse the next working day (“Tomorrow”). After 3:00 PM, it slips to the following slot (“Day after”).

  • Doorstep delivery: After it leaves the warehouse, most addresses get it in about 3–4 days, depending on pincode and courier. Rural or remote areas can take a bit longer.

  • Availability: It should be possible to add Topgraf 0.1% Ointment 10gm to your cart right now. Stock can run out if many people order at once, so finish checkout if you need it soon.

Detailed Information

Introduction

Topgraf 0.1% Ointment 10gm contains tacrolimus, an immunosuppressant medication that helps prevent your body from rejecting a transplanted organ. It works by calming your immune system so it accepts the new organ instead of attacking it. This medicine is used alongside other treatments for people who have received liver, kidney, heart, or other organ transplants.

Tacrolimus belongs to a group of medicines called calcineurin inhibitors. It is a long-term treatment that you will typically need to take for as long as you have your transplanted organ. It is crucial to take this medicine exactly as your doctor prescribes and not to stop taking it without medical advice, as this could lead to organ rejection.

Before starting Topgraf 0.1% Ointment, inform your doctor if you are allergic to tacrolimus or any other ingredients, or if you have a history of liver or heart disease. Report any unusual symptoms such as fever, unexplained tiredness, yellowing of the skin or eyes, or vision changes to your doctor immediately.

Key points

  • Prevents organ transplant rejection by suppressing immune response
  • Long-term maintenance therapy required after transplant surgery
  • Must be taken exactly as prescribed with regular doctor monitoring

Therapeutic Uses

  • Prevention of organ transplant rejection in recipients of liver, kidney, heart, or other organ transplants
  • Management of the immune system to help the body accept a transplanted organ

How it Works

Topgraf 0.1% Ointment works by inhibiting T-lymphocyte activation, which are immune cells that normally attack foreign objects in your body. The medication binds to a protein called FKBP-12, forming a complex that blocks calcineurin phosphatase—an enzyme responsible for triggering immune responses. By suppressing these immune signals, tacrolimus prevents your body from rejecting the transplanted organ while allowing it to function normally.

How to Take

Your doctor will determine the correct dose and duration of treatment based on your specific medical condition, the type of transplant you received, and other individual factors. Always take Topgraf 0.1% Ointment exactly as prescribed and do not change your dose without consulting your doctor.

Instructions

  • Swallow the entire capsule whole with a glass of water
  • Do not open, break, crush, or chew the capsules, as this may affect how the medicine works
  • Take the medicine at the same time each day to maintain consistent levels in your body

Timing

Take on an empty stomach, at least 1 hour before meals or 2 to 3 hours after eating. Consistent meal timing helps maintain steady medication levels.

Missed dose

If you miss a dose, take it as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Never take a double dose to make up for a missed one.

Overdose

If you suspect an overdose, contact your doctor or poison control center immediately. Do not attempt to treat it yourself.

Side Effects

  • Common side effects: swelling in arms or legs, hair loss, itchy skin, constipation or diarrhea, nausea and vomiting, anemia, headache, and cough
  • Serious side effects: irregular heartbeats (increased or decreased), gastrointestinal bleeding, liver injury, seizures, acute kidney failure, and lung infections or respiratory problems
  • If you experience diarrhea lasting more than one day, inform your doctor as it may indicate a medication adjustment is needed

Safety Advice

Pregnancy

Unsafe

Animal studies have shown that tacrolimus may cause harmful effects to an unborn baby. The risks to a developing fetus are not fully understood in humans.

Tip: Inform your doctor immediately if you are pregnant, suspect you may be pregnant, or are planning to become pregnant before starting this treatment. Discuss with your doctor about the potential risks and benefits.

Breastfeeding

Unsafe

Tacrolimus passes into breast milk and may cause harmful effects on nursing infants.

Tip: Do not breastfeed while taking Topgraf 0.1% Ointment. Discuss alternative feeding options with your doctor.

Liver Disease

Consult Doctor

Tacrolimus is processed by the liver. Severe liver disease can affect how your body handles this medication, potentially leading to dangerously high levels.

Tip: If you have liver problems or a history of liver disease, inform your doctor before starting treatment. Your doctor may adjust your dose or monitor your liver function more closely.

Kidney Disease

Consult Doctor

Tacrolimus may affect kidney function, and pre-existing kidney problems may increase this risk. Regular monitoring is necessary.

Tip: Inform your doctor if you have any kidney problems before starting this medication. Your doctor will likely monitor your kidney function regularly during treatment.

Lung Disease

Consult Doctor

The safety of tacrolimus in patients with lung disorders is not well established.

Tip: If you have any lung conditions or respiratory problems, consult your doctor before beginning treatment.

Alcohol

Unsafe

Consuming alcohol while taking Topgraf 0.1% Ointment can cause excessive drowsiness and may increase the risk of liver problems.

Tip: Avoid alcohol completely while taking this medication.

Driving

Consult Doctor

This medication may cause drowsiness and vision problems, which can impair your ability to drive safely.

Tip: Do not drive or operate machinery until you know how this medication affects you. Consult your doctor if you experience any visual disturbances or dizziness.

Sun Exposure

Consult Doctor

Immunosuppressive therapy increases the risk of malignant skin changes and skin cancer from sun exposure.

Tip: Limit sun and ultraviolet (UV) light exposure. Wear protective clothing, sunglasses, and use high-SPF sunscreen (SPF 30 or higher) when outdoors.

FAQs

What if I missed a dose of Topgraf 0.1% Ointment 10gm?
Take your missed dose as soon as you remember. However, if your next scheduled dose is approaching, skip the missed dose and resume your regular dosing schedule. Never take two doses at once to compensate for a missed dose, as this could lead to harmful side effects or overdose.
What should you not use with Topgraf 0.1% Ointment 10gm?
Avoid grapefruit and grapefruit juice, as they can significantly increase the levels of tacrolimus in your blood. Additionally, avoid taking mycophenolic acid-containing products, nelfinavir, and sirolimus without your doctor's approval. Always inform your healthcare provider about all medications, supplements, and herbal products you are using.
How long do I need to take Topgraf 0.1% Ointment 10gm after a transplant?
Topgraf 0.1% Ointment is a long-term maintenance therapy that you will typically need to take indefinitely to prevent rejection of your transplanted organ. The duration depends on how well your body accepts the organ and your individual medical circumstances. Your doctor will monitor your progress and determine whether dose adjustments are necessary over time. Do not stop taking this medication without consulting your doctor.
Can Topgraf 0.1% Ointment 10gm increase the risk of infections?
Yes, because tacrolimus suppresses your immune system, it may increase your susceptibility to infections. Be vigilant about signs of infection such as fever, persistent cough, or unusual fatigue. If you develop signs of infection, contact your doctor immediately. Additionally, consult your doctor before receiving any vaccinations while taking this medication, as the vaccine may not work effectively.
Can Topgraf 0.1% Ointment 10gm affect kidney function?
Yes, tacrolimus can affect kidney function in some patients. Your doctor will likely monitor your kidney function through regular blood tests and urine studies throughout your treatment. If you experience symptoms such as reduced urine output, swelling, or unusual fatigue, inform your doctor immediately. Dose adjustments may be necessary if kidney function changes.

Drug Interactions

Several medications and substances can interact with Topgraf 0.1% Ointment, potentially reducing its effectiveness or increasing the risk of side effects. It is essential to inform your healthcare provider about all medicines you take, including prescription drugs, over-the-counter medications, vitamins, supplements, and herbal products before starting this medication.

Major interactions

  • Grapefruit and grapefruit juice—can increase tacrolimus levels in your blood
  • Mycophenolic acid-containing products
  • Nelfinavir and other protease inhibitors

Precautions

  • Avoid consuming grapefruit and grapefruit juice while taking this medicine
  • Inform your doctor before receiving any vaccinations, as this medicine may interfere with vaccine effectiveness
  • Report all herbal supplements and over-the-counter medications to your doctor

Important

Always maintain an updated medication list with your healthcare provider. Never start or stop any medication without discussing it with your doctor first.

Storage Details

🌡 Store at 25°C (77°F)

Keep in a cool, dry place away from moisture, heat, and direct sunlight

  • Store away from the reach of children and pets
  • Do not freeze or expose to extreme temperatures
  • Keep in original packaging to protect from light and moisture

Fact Box

Active Ingredient
Tacrolimus 0.1%
Drug Class
Calcineurin Inhibitor (Immunosuppressant)
Therapeutic Use
Prevention of organ transplant rejection
Prescription Required
Yes

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Quality Guaranteed

Guaranteed Temperature-Controlled Handling and Shipping — We maintain strict cold chain compliance for temperature-sensitive medicines from storage to delivery.

1

Carefully Packed

Every order is carefully packaged to maintain the required temperature for cold chain medicines and vaccines.

2

Verified Storage

Our pharmaceutical storage facilities are closely monitored and verified to ensure proper temperature conditions.

3

Insulated Shipping

We use insulated containers and temperature monitors for safe transport of temperature-sensitive medicines.

Rx Prescription Required

This medicine requires a valid prescription from a registered medical practitioner (doctor). As per Indian regulations, prescription-only medicines cannot be sold without a valid Rx.

You will need to upload your prescription during checkout. We accept clear images or PDF of your doctor's prescription.

Consult your doctor before taking any medicine. Never self-medicate with prescription drugs.

Medical Disclaimer

MedsRight is committed to providing consumers with reliable, accurate, and expert-validated healthcare information. All content published on this website is intended solely for general informational and educational purposes. It should not be considered a substitute for professional medical advice, diagnosis, or treatment.

We strongly encourage you to consult a qualified doctor or healthcare professional for guidance regarding any medical condition, symptoms, or medications. Never ignore or postpone seeking professional medical advice because of information you have read on MedsRight.

Our goal is to empower patients with trustworthy information while fully respecting and preserving the integrity of the doctor–patient relationship.

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